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Open Access Review

Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling

Rogério Pezato12*, Leonardo Balsalobre1, Milena Lima3, Thiago F P Bezerra4, Richard L Voegels4, Luis Carlos Gregório1, Aldo Cassol Stamm1 and Thibaut van Zele2

Author Affiliations

1 Department of Otolaryngology – Head and Neck Surgery of Federal University of São Paulo, Rua Maestro Antão Fernandes, 173, Jd São Bento, São Paulo, SP02526-060, Brazil

2 Department of Oto-Rhino-Laryngology, Ghent University Hospital, Ghent University, Ghent, Belgium

3 Military Police Hospital, São Paulo, Brazil

4 Department of Otorhinolaryngology and Ophthalmology, University of São Paulo, São Paulo, Brazil

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Journal of Otolaryngology - Head and Neck Surgery 2013, 42:27  doi:10.1186/1916-0216-42-27

Published: 28 March 2013

Abstract

This review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus.

These two theories converge to the same direction in different aspects, including decreased extracellular matrix production, impaired T regulation and favoring of a Th2 immune response.

In patients with nasal polyposis, an exaggerated immune response to Staphylococcus aureus may aggravate the airway remodeling process.

Keywords:
Airway remodeling; Superantigens; Nasal polyps